CRISPR (clustered, regularly interspaced, short palindromic repeats) is a revolutionary new technology that is catalyzing how we approach biomedical research and accelerating new, exciting advances in human and animal health. Adapted from nature where it serves as a sort of bacterial immune system, CRISPR has become a novel and powerful technology to alter the DNA in living, eukaryotic (e.g., mammalian) cells. These alterations can be used for research to study the normal function of genes, modify the function of genes and correct genetic mutations. Efforts are underway to determine the effectiveness and safety of using CRISPR to treat and prevent genetic diseases in animals and humans, reduce transmission of vector-borne diseases like malaria and improve the success of organ transplantation. From these and other areas of research, CRISPR can have an enormous, long-lasting and beneficial impact on our lives and our environment.