Cannabinoids and Pseudocannabinoids

There can be a fine line between therapeutic intervention and substance abuse, and this point is clearly exemplified in herbal cannabis and its products. Therapies involving cannabis have been the treatment of last resort for some types of epilepsy, and this has been among the strongest medical justifications for legalization of marijuana. In order to circumvent the narcotic effects of tetrahydrocannabinol (THC), many studies have focused on its less intoxicating isomer cannabidiol (CBD). However, CBD, like all natural cannabinoids, is a controlled substance in most countries, and its conversion into THC can be easily performed using common chemicals. We will consider the therapeutic potential of fully synthetic analogs of the herbal cannabinoids ("pseudocannabinoids") that are efficacious, legal, non-narcotic, abuse-proof, non-controversial, cheap, and environmentally green.